SLC16A3 and familial pancreatic carcinoma: It has been confirmed that MCT4 depletion can trigger a metabolic crisis that invokes compensatory mechanisms related to multiple metabolic pathways, including oxidative phosphorylation, macropinocytosis, autophagy, and nutrient‐scavenging mechanisms in pancreatic cancer research.22 To determine whether the adaptive biological response of induced autophagy was relative to MCT4 inhibition, we analyzed whether autophagy was increased in the inhibition of MCT4 in 4T1 cells.