Compared with HIV‐negative patients, HIV‐positive patients had a lower peak alanine aminotransferase (ALT) level (median, 1312 vs. 2014 IU/L, p = 0.003), less coagulopathy (6.0% vs. 16.2%, p = 0.007), less hepatomegaly or splenomegaly on imaging studies, but delayed resolution of hepatitis (40.9% vs. 21.3%, p = 0.005). The gene discussed is GPT; the disease is Splenomegaly.