The results showed that the binding ability of PGC1β and RXRβ on the LDHA promoter was significantly increased in MM cells compared to the NBL control group, while the binding ability of RXRα on the LDHA promoter showed no difference, indicating that PGC1β and RXRβ may bind to the LDHA promoter and be responsible for LDHA activation, while RXRα has no effect. This evidence concerns the gene LDHA and Miyoshi myopathy.