Recent studies have shown that PGC1β is upregulated in cancer cells and promotes tumorigenesis by regulation of mitochondrial biogenesis and glycolysis metabolism (Bellafante et al., 2014; Chang et al., 2011; Deblois et al., 2010; Deblois et al., 2013), while the detailed mechanism still needs to be fully understood. This evidence concerns the gene PPARGC1B and cancer.