We found that overexpression of PGC1β or LDHA increased tumor colony formation in the lung by 191% or 152%, respectively, while knockdown of PGC1β or LDHA reduced colony formation by 68% or 37%, respectively, and LDHA had significantly less of an effect than PGC1β in both overexpression and knockdown. The gene discussed is LDHA; the disease is neoplasm.