CDH1 and gastric cancer: Gastric cancers of the diffuse type are particularly lacking inflammation in the presence a germline mutation in CDH1.10 Hence, Shah et al.11 advocated that the Lauren classification be modified to include both the Lauren histopathologic classification and the anatomic location of GC, yielding at least three entirely distinct types, namely, the proximal non-diffuse type (PND), the distal non-diffuse type (DND), and Lauren’s diffuse type (D).