SRSF1 and familial dilated cardiomyopathy: The same group demonstrated a year later that cardiomyocyte-specific knockout of another SR protein family member alternative splicing factor 2 (ASF/SF2) (also known as SRSF1) results in the development of DCM by week 6 after birth and rapidly progression in heart failure, where mice die around week 8 (Xu et al. 2005).