The activation of HPA axis in severe illnesses, such as trauma, anesthesia, major surgery, burns, and sepsis, is the main mechanism for adjustment of homeostasis in the body and interaction between immune and adrenal system, neuronal stimulation of CRH, release of adrenocorticotropic hormone (ACTH), cortisol, and a variety of cytokines which are essential for a sufficient response to stress [1, 2, 5, 9, 12, 14, 20, 27]. The gene discussed is POMC; the disease is Sepsis.