In the current study, we examined the numbers of circulating Foxp3+Tregs and Th1-Th17-Th22 cells, and the concentration of serum inflammatory cytokines in AIH patients, and used the mouse model of EAH to investigate the biological importance of Tregs and Th1/Th17/Th22 cells in the pathogenesis of AIH. This evidence concerns the gene FOXP3 and autoimmune hepatitis.