Further comparison of different types of effector CD3+CD4+T cells found that AIH patients undergoing an active state had significantly increased numbers of CD3+CD4+IFN-γ+Th1, CD3+CD4+IL-17+Th17, and CD3+CD4+IL-22+Th22 cells and higher levels of serum Th1 cytokine IFN-γ, Th17 cytokine IL-17A, and Th22 cytokine IL-22, compared to AIH patients in remission and HC (Figure 2). This evidence concerns the gene IL22 and autoimmune hepatitis.