POSTN and asthma: In 2015, in a phase II clinical study of using lebrikizumab to patients with moderate-to-severe uncontrolled asthma despite ICS therapy and an additional controller, subcutaneous administration of lebrikizumab taken every four weeks reduced asthma exacerbation rate by 60% compared with placebo in periostin-high patients and by 5% in periostin-low patients.