In a clinical model of increased histamine release, patients with chronic urticaria, higher platelet activity was observed when compared to healthy controls: increased levels of soluble P-selectin in one study [80] and both enhanced aggregation in response to ADP and increased soluble P-selectin levels compared to healthy population in another paper (both parameters were strongly and positively correlated with the Urticaria Severity Score) [81]. This evidence concerns the gene SELP and urticaria.