CBS and neoplasm: Additional investigations are clearly required to better elucidate the complex role of CBS in malignant transformation including (i) characterizing the role of CBS-related metabolic signaling in cancer pathogenesis including but not limited to CBS, Hcy, H2S, and the related enzymes; (ii) determining the interaction of tumor cell-derived CBS and its metabolites with the microenvironment; (iii) identifying biomarkers of CBS-based therapies in clinical samples and cancer models.