In support of this finding with nestin+ NSCs, a recent study revealed connection between nestin and p53 into liver cancer cells, where they showed that p53-dependent nestin regulation in hepatocellular carcinomas and cholangiocarcinomas cells and this connection regulates cellular plasticity and tumorigenesis in liver cancer (Tschaharganeh et al., 2016). Here, NES is linked to cholangiocarcinoma.