In support of this finding with nestin+ NSCs, a recent study revealed connection between nestin and p53 into liver cancer cells, where they showed that p53-dependent nestin regulation in hepatocellular carcinomas and cholangiocarcinomas cells and this connection regulates cellular plasticity and tumorigenesis in liver cancer (Tschaharganeh et al., 2016). This evidence concerns the gene TP53 and liver cancer.