Our study of the GBM39 PDX model, arrived at 4 key findings and 2 recommendations: (1) tumor EC-like subpopulations have high concentrations of plasma membrane VEGFR1 and VEGFR2; (2) human vs. mouse tumor EC-like cells have inverted VEGFR2:VEGFR1 ratios; (3) tumor EC-like subpopulations have high plasma membrane EGFR, IGFR, and PDGFR concentrations; and (4) GSCs compose a low percentage of cells in the tumor and have little-to-no EGFRs and IGFRs on their plasma membranes. This evidence concerns the gene IGF1R and neoplasm.