Of special note, cytosporone B (7) was reported as a nuclear orphan receptor Nur77 agonist as a promising therapeutic drug for cancers and hypoglycemia (Zhan et al., 2008), as well as the transcription factor NR4A1 agonist to control IAV infection and improve pulmonary function in infected mice (Xia et al., 2013; Egarnes et al., 2017), which had aroused a great interest for chemical synthesis study (Von Delius et al., 2017). This evidence concerns the gene NR4A1 and cancer.