It is possible that genetic predisposition is linked to Vit D deficiency, in fact, Conti et al.[24] investigated the effect of two single polymorphisms of the vitamin D receptor (VDR) gene in modulating bone mineral density (BMD) and the response to treatment with bisphosphonates or strontium ranelate in postmenopausal osteoporosis. Here, VDR is linked to postmenopausal osteoporosis.