PRDX4 and metabolic dysfunction-associated steatotic liver disease: Whereas Prdx4-knockout (Prdx4−/y) mice show no apparent phenotypic abnormality except for testicular atrophy [17], it has been reported that the human Prdx4 transgene renders nongenetic models of NAFLD and/or type 2 diabetes mellitus resistant to the progression of the pathology [18].