There were 4 inflammation-related pathways shown in signal transduction module, including TNF signaling pathway (degree=9), NF-kappa B signaling pathway (degree=6), HIF-1 signaling pathway (degree=9), and VEGF signaling pathway (degree=4), and these pathways indicated that the anti-inflammatory action is important for the treatment of AD. Here, HIF1A is linked to Alzheimer disease.