Another study has reported that resveratrol can ameliorate mitochondrial dysfunction, decrease malondialdehyde and uncoupling protein 2 expression, increase peroxisome proliferator-activated receptor gamma coactivator 1-alpha deacetylation, and improve cardiac dysfunction and myocardial hypertrophy by upregulating SIRT1 expression in the myocardium of diabetic rats [43]. Here, PPARGC1A is linked to cardiac hypertrophy.