RBM20 and familial dilated cardiomyopathy: In an attempt to find a novel pre-clinical biomarker for DCM, genome-wide analysis of 8 families with DCM uncovered distinct heterozygous missense mutations in exon 9 of RBM20. These mutations segregated with the DCM phenotype, which led to the recognition of RBM20 as a DCM-causing gene (Brauch et al., 2009).