Most reported cardiomyopathy-related mutations in the RBM20 gene arise in the RS region which includes a five-amino acid mutation “hotspot” within exon 9 (Brauch et al., 2009; Li et al., 2010; Millat et al., 2011; Rampersaud et al., 2011; Refaat et al., 2012; Guo et al., 2012; Wells et al., 2013; Klauke et al., 2017; Long et al., 2017). This evidence concerns the gene RBM20 and cardiomyopathy.