FH and age-related macular degeneration: CFHR1*A is in strong linkage disequilibrium with the AMD-risk CFH402His allele, and CFHR1 genotyping has similar predictive value of developing AMD as CFH402His;ΔCFHR3–CFHR1 genotyping (160); these findings are suggestive of a direct role of FHR-1 in AMD pathogenesis, most likely by interfering with the interaction of FH with specific ligands and promoting complement activation (33).