Nonetheless, the strong association of ΔCFHR3–CFHR1 with high FH levels, together with the finding that FHR-1 levels were lower in AMD patients than in control individuals, suggests that ΔCFHR3–CFHR1 is actually tagging an allele expressing high FH levels, but it is not causal in protection against AMD (8). This evidence concerns the gene FH and age-related macular degeneration.