Due to the effector role CD8+ and CD4+ T cells play in pathogenesis of celiac disease, the impact of anti-IL-15 treatment on small intestinal CD3+CD4−CD8+CD45+ and CD3+CD4+CD8−/+CD45+ T cells secreting IFN-γ was evaluated (Figures 4A–F). This evidence concerns the gene CD8A and celiac disease.