FDPS and neoplasm: After these findings, nitrogen-containing bisphosphonates (N-BPs) like Zoledronic acid have emerged as drugs that, indeed, can raise up the intracellular levels of IPP by the inhibition of farnesyl diphosphate synthase (FPPS) (40, 41), thus facilitating the activation of human Vγ9Vδ2 T cells against tumor cells.