CTLA4 and neoplasm: In addition, it has been shown that IDO-expressing tumors promote differentiation and activation of regulatory T cells (Tregs) (9, 14, 15), which in turn can induce IDO expression in myeloid cells via cytotoxic T-lymphocyte-associated protein-4 (CTLA-4)–CD80/86 interactions (16) and recruit myeloid-derived suppressor cells (MDSCs) to the tumor site (17, 18).