GPER1 and breast carcinoma: It has been shown that GPR30 can mediate estradiol proliferative effects in thyroid (Vivacqua et al., 2006a), endometrial (Vivacqua et al., 2006b), ovarian (Albanito et al., 2007) and GPR30-positive SKBr3 breast cancer cell lines (Albanito et al., 2008).