As showed in our results, compared with both the non-CAD control group and CAD group, serum IL-34 levels were significantly elevated in subjects with ICM, correlated with NT-proBNP level, echocardiography parameters, including LVEF, LVEDD, LVESD and LAD, as well as with NYHA functional class, suggesting its function in the process of HF. The gene discussed is NPPB; the disease is coronary artery disorder.