Multivariable linear regression analysis further verified a significant relationship between IL-34 level and NT-proBNP level (β = 0.171, P < 0.001) after adjusting for age, sex, BMI, history of hypertension, history of DM, and levels of hsCRP, hemoglobin, albumin, HbA1c, as well as eGFR (Table 2). This evidence concerns the gene NPPB and hypertensive disorder.