MYD88 and obesity due to melanocortin 4 receptor deficiency: This hypothesis is further enhanced by Everard et al. (2014) who demonstrated that intestinal deletion of MyD88, a central adaptor molecule for the majority of toll-like receptors, including TLR4, partially protected obese-prone mice and germ-free mice who received a faecal microbiota transplant from obese-prone mice from diet-induced obesity and inflammation.