INS and Insulin resistance: Although these differences could be technical and therefore should not be over interpreted, these miRNAs have also all been described to be regulated in model systems of muscle insulin resistance or T2DM (Blumensatt et al., 2013, 2014; Zhang et al., 2013; Riches et al., 2014) or glucose uptake and insulin sensitivity (Jordan et al., 2011; Zhou et al., 2016), suggesting a functional relevance of this finding.