INS and type 2 diabetes mellitus: Furthermore, Massart et al. (2017) recently showed that miR-29a and miR-29c were increased in skeletal muscle tissue from patients with T2DM and regulated insulin-mediated glucose metabolism, and miR-29b has similarly been shown to be increased in T2DM muscle (He et al., 2007; Gerlinger-Romero et al., 2017).