UQCRFS1 and cyclic hematopoiesis: Additionally, the relationship between mitochondrial ROS and PA remodeling in response to CH is supported by the observation that depletion of Rieske iron-sulfur protein (RISP), a mitochondrial complex III protein that is required for ROS generation, in mouse ECs and SMCs prevents CH-induced PH (Guzy and Schumacker, 2006; Waypa et al., 2016).