The role of IF1 in acinar-to-ductal metaplasia and functions of IF1 in pancreatic ducts, which are known to be susceptible to mitochondrial damage in conditions of acute pancreatitis [(Biczo et al., 2011; Maleth et al., 2011) reviewed in (Maleth and Hegyi, 2016)], are interesting subjects for further investigations. Here, ATP5IF1 is linked to acute pancreatitis.