MB and Renal insufficiency: Muscle cell damage and death (rhabdomyolysis) result in the release of creatine phosphokinase (CK) and myoglobin among other intracellular molecules, while the accumulation of myoglobin in the kidneys can lead to renal failure and death (Pasternak et al., 2002; Tomaszewski et al., 2011; Catapano et al., 2016).