PCSK9 and aortic valve stenosis: Prompt diagnosis and early initiation of aggressive treatmentEarly identification of CAD (especially ostial disease and AS)In addition to lifestyle, statins should be started even in receptor-negative patientsCombination therapy usually required (mipomersen, lomitapide, PCSK9 inhibitors)LA necessary in many casesLiver transplantation is an option if available in timeGene therapy seems promising, but needs more clinical trials