Investigation of the monogenic form of FH includes testing for pathogenic variants in the genes for LDLR, ApoB, PCSK9 (related with the autosomal dominant type), and LDLRAP1 (autosomal recessive form) (Harada-Shiba et al., 2012a; Ito and Watts, 2015). The gene discussed is LDLRAP1; the disease is familial hyperaldosteronism.