These findings are compatible with postmortem studies of AD brains, revealing decreases of PDHC and TCA enzymes as well as cholinergic markers including ChAT, high affinity choline uptake (HACU), M2 muscarinic autoreceptors, and VAChT (Terwel et al., 1998; Pappas et al., 2000; Bubber et al., 2005; Mufson et al., 2008; Potter et al., 2011; Jagust et al., 2015). The gene discussed is CHAT; the disease is Alzheimer disease.