Similar conditions may occur in the brains of AD 2576Tg and 3xTg mice, in which sub micromolar Aβ accumulation was accompanied by mental impairment, suppression of pyruvate uptake, a drop of acetyl-CoA content and ACh synthesis in nerve terminals at non-altered PDHC and ChAT activities (Yao et al., 2009; Bielarczyk et al., 2015). The gene discussed is CHAT; the disease is Alzheimer disease.