However, although these other molecules have also shown the capability to prevent the downregulation in ChAT, or other aspects of motoneuron physiology, their lack does not cause adult-onset ALS-like motoneuron degeneration and paralysis in mice, as happens for VEGF (Oosthuyse et al., 2001; Lambrechts and Carmeliet, 2006; Gould and Oppenheim, 2011; Tovar-y-Romo et al., 2014). Here, CHAT is linked to amyotrophic lateral sclerosis.