VEGFA and amyotrophic lateral sclerosis: In this regard, a great interest in VEGF has emerged after the recent link established between low levels of this factor and the motoneuronal neurodegenerative disease amyotrophic lateral sclerosis (ALS; Oosthuyse et al., 2001; Sathasivam, 2008), a severe pathology that courses with motoneuronal death and lethality in a few years subsequent to the onset of the disease (Cleveland and Rothstein, 2001; Robberecht and Philips, 2013; Turner et al., 2013).