ADORA2A and Alzheimer disease: Indeed, neuronal upsurge of A2AR have been observed in the brain of AD patients (Temido-Ferreira et al., 2018) and recent work demonstrated that APP/PS1 mice exhibit a significant increase of A2AR binding on synaptic hippocampal membranes (Viana da Silva et al., 2016; Silva et al., 2018).