AD is characterized by a progressive cognitive decline and neuropathologically defined by two hallmarks: extracellular deposits constisting of aggregated β-amyloid (Aβ) peptides and intraneuronal fibrillar aggregates of hyper- and abnormally phosphorylated Tau proteins (Masters et al., 1985; Duyckaerts et al., 2015). This evidence concerns the gene MAPT and Alzheimer disease.