For instance, synaptic A2AR have been found dysregulated in models of aging, stress or depression with behavioral manifestations normalized by A2AR receptor antagonists (Lopes et al., 1999; Rebola et al., 2003; Batalha et al., 2013; Kaster et al., 2015; Machado et al., 2017). Here, ADORA2A is linked to depressive disorder.