Similar to what has been previously described in AD patients and in different APP models (Orr et al., 2015, 2018; Lee et al., 2018), we observed that APP/PS1 mice exhibit a progressive hippocampal upsurge of A2AR immunoreactivity (Figures 1G–I), as compared to WT littermates (Figures 1A–C). Here, APP is linked to Alzheimer disease.