Interestingly, confocal microscopy showed that phosphorylated TDP-43 accumulated in the VGLUT-1-positive axon terminals in the striatum of FTLD-TDP and ALS-TDP patients, indicating that aggregations of phosphorylated TDP-43 may play some role in the destruction of VGLUT-1-positive terminals. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.