Riku et al. demonstrated that striking depletions of vesicular glutamate transporter-1 (VGLUT-1)-positive axon terminals in the caudate head and putamen were observed in all 46 FTLD-TDP patients examined (31 with FTLD-TDP and 15 with ALS-TDP) (Riku et al., 2017). This evidence concerns the gene SLC17A7 and amyotrophic lateral sclerosis.