Similar sequential distributions of pTDP-43 pathology were also reported in bv FTD patients with TDP-43 Type A or Type B pathology: stage 1, orbital and amygdala; stage 2, additional frontal, temporal, and subcortical regions; stage 3, motor system involvement; and stage 4, visual cortex (Brettschneider et al., 2014). Here, TARDBP is linked to frontotemporal dementia.