Our selected CFA/I docking site encompassed the amino acids V24EKNITVTASVD35 of the highly conserved CfaB Ig-like groove, found in major subunits of ETEC CFA/I related CFs (Supplementary Figs S2 and S5 online) and class 1 pili of bacteria that can cause urinary and respiratory infections by binding to host glycolipids containing HBGAs9,17. The gene discussed is CFB; the disease is respiratory tract infectious disorder.