Inversely, ProMisE subgroups were distributed among L1CAM-positive tumours as follows: 7/97 (7.2%) POLE, 26/97 (26.8%) MMR-D, 19/97 (19.7%) p53 wt/NSMP, and 45/97 (46.3%) p53 abn (Fig. 1c). Here, TP53 is linked to neoplasm.