This is most important for intermediate-risk groups of MMR-D and p53 wt/NSMP tumours, which constitute a large percentage of cases (64–79%).11,12,15 Our study demonstrates that L1CAM expression correlates with high grade, high stage, and poor prognosis for OS and DSS within the p53 wt/NSMP subgroup of EC, which agrees with previous studies on similar cohorts.14,31. The gene discussed is TP53; the disease is neoplasm.