L1CAM and neoplasm: A similar negative prognostic effect of L1CAM expression in the other intermediate-risk group of MMR-D tumours was recently demonstrated;14,31 we observed a similar trend; however, statistical significance was not reached in our cohort (Table 2A); our study cohort is heterogeneous in stage, ESMO-risk group, treatment, and has relatively few L1CAM-positive tumours, which limited our power to study the prognostic significance of L1CAM in specific subgroups of tumours.