TP53 and neoplasm: Kaplan–Meier analyses showed significantly worse outcome for L1CAM positive, p53 wt/NSMP tumours with 5-year OS rates of 88.2% for L1CAM negative and 51.5% for L1CAM-positive tumours (Fig. 2c; p < 0.001), and 95.5% for L1CAM negative and 65.5% for L1CAM-positive tumours for 5-year DSS (Fig. 2d; p < 0.001).