In addition, coadministration of AS605240 and three flavonoids resulted in the virtual abrogation of Akt, mTOR, p70S6K, and ULK activations (Fig. 7E,F, Fig. S8C and S8D), Together, these findings suggest that downregulation of PI3Kγ plays a critical role in regulating the lethality of three flavonoids in human breast cancer cells. Here, AKT1 is linked to breast cancer.