NPM1 and acute myeloid leukemia: In the present study, we therefore examined the effect of several proteins including molecular chaperons on the aberrant eye morphology phenotype induced by wild-type hFUS. By screening, we have found that the co-expression of nucleophosmin–human myeloid leukemia factor 1 (NPM-hMLF1) fusion protein could suppress the aberrant eye morphology phenotype induced by hFUS. Fusion protein NPM-hMLF1 is produced by the t(3;5) (q25.1;q34) chromosomal translocation, associating with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML)42,43.