Several recent studies have demonstrated that miR-22, miR-27b, miR-206, miR-221, miR-433, and miR-548m are involved in the regulation of HDAC6 in cutaneous T-cell lymphoma, large B-cell lymphoma, head and neck squamous cell carcinoma, liver cancer, oral squamous cell carcinoma, and non-Hodgkin B cell lymphomas, respectively27–32. Here, HDAC6 is linked to head and neck squamous cell carcinoma.