Figure 4e shows that tumors xenograft of mice treated with miR-205 LNA inhibitor expressed about 50% less of miR-205-5p and immunohistochemistry analysis (Fig. 4f) confirmed that tumor xenograft of LNA-i-mir-205-5p group showed significant reduction of Ki67-positive cells, thus a reduced proliferation rate. Here, MKI67 is linked to neoplasm.