SNCA and Parkinson disease: We have recently shown that even moderate impairment of DNA repair systems - including NER, transcription-coupled repair (TCR), and double-strand break repair pathways (DSB) - facilitates the onset of pathological features typical of PD that include derangement of the dopaminergic system, mitochondrial dysfunction and complex I activity suppression, and increased alpha-synuclein phosphorylation13.