Of these, PLAT, which encodes tPA was most up-regulated in IPF epithelial cells (Fig. 7a; Supplementary Table S1) and we confirmed enhanced secretion of tPA in the CM from 4-OHT-treated ATIIER:KRASV12 cells by Western blotting (Fig. 7b). This evidence concerns the gene PLAT and idiopathic interstitial pneumonia.