To assess the mechanism of KCNB1 oxidation in the human brain we obtained post mortem hippocampal tissue of 6 AD donors (3 females and 3 males, average age 83.8 years) and 6 age-matched controls (3 females and 3 males, average age 82.5 years) from the Harvard Brain Tissue Resource Center through the Neurobiobank repository of the NIH. This evidence concerns the gene KCNB1 and Alzheimer disease.