We constructed 4xTg mice by cross-breeding 3xTg-AD with transgenic mice that expresses a non-oligomerizabe variant of KCNB1 obtained by replacing Cys73 to Ala (Tg-C73A) or the WT channel (Tg-WT) as control, in cortex and hippocampus which we characterized previously7. The gene discussed is KCNB1; the disease is Alzheimer disease.