Since oxidation of KCNB1 is associated to both amyloidosis and oxidative stress, we assessed the levels of hyperphosphorylated tau in the brains of 1-year-old mice by IHC, using an antibody that detects phosphorylated tau at Ser199 (Fig. 9a, b), and phosphorylated tau at Ser356 (Fig. 9c). This evidence concerns the gene KCNB1 and amyloidosis.