In the same study, alterations of DNA methylation in subcutaneous adipose tissue were found in T2D twins in promoter regions of the following genes: ADCY5, CAV1, CIDEC, CDKN2A, CDKN2B, DUSP9, HNF4A, IDE, IRS1, KCNQ1, MTNR1B, TSPAN8, and WFS1 [69]. The gene discussed is IRS1; the disease is type 2 diabetes mellitus.