Besides TCF7L2, PPARG, and KCNJ11 loci, the most replicated T2D susceptibility variants identified in GWASs were found in and around CDKN2A/2B, IGF2BP2, SLC30A8, CDKAL1 and FTO genes [12,13,14,15]. The gene discussed is KCNJ11; the disease is type 2 diabetes mellitus.