In skeletal muscle of T2D patients, higher expression of let-7f-5p was shown to be associated with the lower expression of INSR and IRS2. In another study, the lower expression of miR-15b-5p in human T2D skeletal muscle was associated with the lower expression of IRS1 and INSR [76]. The gene discussed is IRS1; the disease is type 2 diabetes mellitus.