RUNX2 and neoplasm: The role of RUNX2 in osteoblastic differentiation and calcification has been demonstrated in previous studies [33,34], and recently Carr et al. suggested that dysregulation of THRβ, which acts as a tumor suppressor gene, and the concomitant increase in the expression of RUNX2, which acts as a tumor promotor, are associated with the development of thyroid cancer [32].