CD4 and neoplasm: Two studies using combination antibody immunotherapy, anti-PD-1 and -OX40 [142] or anti-PD-1 and -CTLA-4 and -CD137 [129] have shown prolonged survival of ID8 tumor-bearing mice and a shift from a CD4+ T helper 2 (Th2) cell milieu to an antitumor Th1 response characterized by an increased ratio of CD8+ and CD4+ T cells over immunosuppressive CD4+FOXP3+ Tregs, and a reduction in CD11b+Gr-1+ MDSCs.