BRCA1 and neoplasm: The peritoneal cavity is the main locus for EOC metastases, and local treatment seems to be a safer option for patients, because adverse reactions induced by ‘on-target off-tumor’ toxicities, such as cytokine release syndrome, were reported in a study that used ACT of autologous mesothelin-redirected CAR-T cells in a patient with BRCA1+ advanced recurrent serous EOC [39].