These co-inhibitory molecules include cytotoxic T-lymphocyte associated protein 4 (CTLA-4; on T cells to control T cell activation, and binds to CD80 or CD86 on APCs or tumor cells), lymphocyte-activation gene 3 (LAG-3; on T and NK cells, and binds to MHC-II and LSECtin on APCs or tumor cells [58]), programmed cell death protein 1 (PD-1; on activated T, B, and NK cells, and binds to PD-L1 or PD-L2 on APCs or tumor cells), and PD-L1 (on APC or tumor cells, and binds to PD-1 on T cells or CD80 on APC or tumor cells). This evidence concerns the gene LAG3 and neoplasm.