TLR4 and neoplasm: Paclitaxel has been previously reported to be a ligand to Toll-like receptor 4 (TLR4), normally found on normal and neoplastic cells, which, under ligation, significantly increase the secretion of IL-6 and IL-8 by human EOC cell lines (SKOV3, OVCAR3), abrogating paclitaxel effects on cell proliferation, and promoting tumor survival and chemoresistance [77,78,79].