MDSCs, TAMs, and regulatory T cells (Tregs) play a critical role in maintaining a highly immunosuppressive TME by producing immunomodulatory molecules [transforming growth factor beta (TGFβ), interleukin (IL)-10, IL-6, etc.] and inducing and recruiting immunoinhibitory cells, which dampens antitumoral immunity and supports tumor promotion [12,14]. Here, TGFB1 is linked to neoplasm.