AOPEP and Alzheimer disease: However, in Pakistani population APO E4 alleles and ATP7B variant alleles are known genetic factors increasing the risk of AD [51], which is also corroborated with a the results of a large prospective cohort study confirmed case–control reports that women who are positive for the ε4 allele of the apolipoprotein E gene (APOE ε4) are at greater risk of developing AD [52].