HMGB1 and cancer: As a matter of fact, overexpression of HMGB1 is associated with each of the hallmarks of cancer as described by Hanahan and Weinberg [46], namely unlimited replicative potential, ability to develop blood vessels (angiogenesis), evasion of programmed cell death (apoptosis), self-sufficiency in growth signals, insensitivity to inhibitors of growth, inflammation, tissue invasion and metastasis [7].