Overexpression of HMGB1 in tumor tissue and increased HMGB1 serum level are near-universal in virtually every examined type of cancer, including colon carcinoma [11–13], hepatoma [14,15], breast cancer (BC) [16], pancreatic cancer [11], melanoma [17], ovarian cancer [18], and mesothelioma [19,20], indicating a carcinogenic role of HMGB1. Here, HMGB1 is linked to hepatocellular carcinoma.