Among those related with neurological disorders, epm2a (Lafora disease), serpini1 (encephalopathy familial with neuroserpin inclusion bodies), il1rpl1 (autism and mental retardation X-linked 21) and scn4a (hyperkalemic peridoc paralysis), are particularly interesting for their essential role in these diseases, indicated by the “reliability score” of the gene-disease pair (Table 1). This evidence concerns the gene SERPINI1 and nervous system disorder.