It should be noted that streptozotocin-induced diabetic mice (resembling type 1 diabetes), that are used in most studies elucidating the effects of other SGLT-2 inhibitors, are characterized by markedly increased glucose levels which result in more detrimental effects on various inflammatory and metabolic parameters contributing to atherosclerosis, thus their beneficial effects could be more pronounced. The gene discussed is SLC5A2; the disease is atherosclerosis.