Our experiments are supported by other studies in which low-level laser irradiation alone attenuates aneurysm progression in the Ang II-infused ApoE−/− mouse in vivo [27], which is linked to a modification in anti-inflammatory processes in macrophages such as inhibition of gene expression of pro-inflammatory cytokines IL-1α, IL-1β, and IL-6 and the chemoattractant CCL2 [28]. Here, APOE is linked to aneurysm.